Could Viagra Put the Brakes on Jet Lag?
TUESDAY, May 22 (HealthDay News) — Worried about jet lag? Researchers think they might have just the ticket to perk you up: Viagra.
While it's too early to know if it will work in humans, Argentinean researchers are reporting that the drug sildenafil — better known by the brand name Viagra — appears to reduce symptoms of jet lag in hamsters.
Viagra does come with potential side effects, and some men might not appreciate a temporary respite from erectile dysfunction at 30,000 feet. Still, a sleep specialist called the research promising.
“We do need more effective therapies for jet lag and for sleep that occur as a consequence of shift work,” said Dr. Robert Vorona, an associate professor at Eastern Virginia Medical School who's familiar with the study findings.
In the study, researchers administered small doses of sildenafil to hamsters before adjusting the cycles of light and dark they lived in. This reset their body clocks as if they'd taken a six-hour plane trip to the east.
The hamsters recovered 25 percent to 50 percent more quickly from the equivalent of human jet lag, needing less time to synchronize themselves to the new schedule, said Dr. Diego Golombek, a researcher with the Universidad Nacional de Quilmes in Buenos Aires. He said sildenafil worked at least as well as melatonin, a jet-lag treatment.
But the drug didn't help hamsters who underwent a simulation of westward jet travel.
The findings were published in this week's Proceedings of the National Academy of Sciences
The drug, originally developed to treat high blood pressure and angina, might alleviate jet lag by with a molecule that sends signals to the hamster brain's body clock mechanism, Golombek said.
But the potential impact on humans isn't clear, and Golombek said people shouldn't rush out to prevent jet lag with doses of Viagra. For one thing, Viagra can cause side effects such as low blood pressure.
As for the next step, Golombek said “a full-scale clinical trial has to be performed in humans, which is indeed quite expensive and time-consuming. Jet-lag trials might involve laboratory simulations, but we also need 'the real thing,' which means testing pharmacological treatments on long-haul air travel.”
And that, he added, will take even more time.
More information
For more information on jet lag, visit the National Sleep Foundation.
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